The Scalabrini Apostleship of the Sea Network serves seafarers in port cities across the globe. Workers in the cruise, shipping, and fishing industries can spend weeks or even months at sea for little pay with no connection to their loved ones. The Scalabrini congregation has organized teams of priests and Catholic laypeople to board ships and minister to them through masses and blessing ceremonies. The centers of the Scalabrini Apostleship of the Sea Network also offer a number of services in port cities, including shelter, training programs, access to international telephone lines and internet to connect with family members, recreation centers, lending libraries, television, shopping, and more.

Scalabrini missionaries run Apostleship of the Sea centers in Argentina, Brazil, Italy, the Philippines, South Africa, Taiwan, and Uruguay.